The effect of taxol and ASA404 as sole agents or in combination on xenograft volume at different time points [A] and weight [B] at the end of treatment. The treatment of animals with taxol did not affect xenograft growth in comparison to untreated controls. Treatment with ASA404 alone or in combination with taxol caused significant growth delay of tumors in comparison to control or animals which were treated with taxol as a sole compound. There was not significant difference in tumor growth delay between animals which were treated with ASA404 alone or in combination with taxol. On the end of the treatment, the tumor weight of animals treated with the ASA404 and taxol combination were significantly lower than from animals which were treated only with ASA 404.
Milanović et al. BMC Cancer 2012 12:242 doi:10.1186/1471-2407-12-242