Open Access Research article

Estimation of groin recurrence risk in patients with squamous cell vulvar carcinoma by the assessment of marker gene expression in the lymph nodes

Magdalena Kowalewska1*, Jakub Radziszewski2, Krzysztof Goryca34, Mateusz Bujko1, Malgorzata Oczko-Wojciechowska5, Michal Jarzab5, Janusz Aleksander Siedlecki1 and Mariusz Bidzinski6

Author Affiliations

1 Department of Molecular Biology, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Roentgena, 5, Warsaw 02-781, Poland

2 Department of Surgery, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Wawelska 15, Warsaw 00-973, Poland

3 Department of Oncological Genetics, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Roentgena 5, Warsaw 02-781, Poland

4 Laboratory of Bioinformatics and Systems Biology, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Roentgena 5, Warsaw 02-781, Poland

5 Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Wybrzeze Armii Krajowej 15, Gliwice 44-100, Poland

6 Department of Gynecological Oncology, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Roentgena, 5, Warsaw 02-781, Poland

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BMC Cancer 2012, 12:223  doi:10.1186/1471-2407-12-223

Published: 6 June 2012

Additional files

Additional file 1:

Table S2. Genes differentially expressed in LN(+) and LN(−) sample obtained from VC patient No 15. Abbreviations: P - p value; cP - Benjamini-Hochberg corrected p value; FC - fold change of gene expression ratio in LN(+) and LN(−) sample; exp. - expression level.

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Additional file 2:

Table S3. Genes differentially expressed in the four LN(+) and LN(−) sample pairs obtained from VC patients No 15, 21, 46 and 61. Abbreviations: P - p value; NA - not applicable.

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Additional file 3:

Table S1. Mean levels of expression of PERP, S100A8, FABP5, SFN, CA12, JUP and CSTA in LN(+) and LN(−) samples, measured by qRT-PCR. Abbreviations: ME – mean expression level in all involved [LN(+)] and uninvolved [LN(−)] lymph node samples included in the qRT-PCR analysis.

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