Open Access Highly Accessed Research article

Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia

Evgeny A Moskalev17*, Katrin Luckert2, Ivan A Vorobjev34, Sergey E Mastitsky5, Aleena A Gladkikh3, Achim Stephan1, Marita Schrenk1, Kamil D Kaplanov6, Olga B Kalashnikova6, Oliver Pötz2, Thomas O Joos2 and Jörg D Hoheisel1

Author Affiliations

1 Functional Genome Analysis, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany

2 Biochemistry Department, NMI Natural and Medical Sciences Institute at the University of Tübingen, Markwiesenstr. 55, 72770, Reutlingen, Germany

3 Functional Morphology of Hemablastoses, National Hematology Research Centre of Russian Academy of Medical Sciences, Novy Zykovsky passage 4a, 125167, Moscow, Russia

4 A.N. Belozersky Institute and Biological Faculty, Moscow State University, Leninskie Gory 1, 119991, Moscow, Russia

5 Theoretical Bioinformatics, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany

6 Department of Haematology, Volgograd Regional Clinical Oncological Dispensary No.1, Zemlyachki str. 78, 400138, Volgograd, Russia

7 Diagnostic Molecular Pathology, Institute of Pathology, University of Erlangen-Nürnberg, Krankenhausstr. 8-10, 91054, Erlangen, Germany

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BMC Cancer 2012, 12:213  doi:10.1186/1471-2407-12-213

Published: 6 June 2012

Additional files

Additional file 1:

Table S1. Demographic and clinical characteristics of CLL patients and healthy donors.

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Additional file 2:

Table S2. The optimal GLS models found for each of the examined genes by a stepwise backward reduction of the full model described in Material and Methods.

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