Table 5

Antioxidant micronutrients from food and supplements and ovarian cancer risk
Cases (n) Controls(n) OR1 95 % CI OR2 95 % CI
    Vitamin C
Food (mg)
1 (<82.3) 75 127 1.00 1.00
2 (82.3-141.7) 72 132 0.93 0.58-1.48 1.08 0.65-1.79
3 (
    >
141.8)
58 128 0.99 0.59-1.67 1.29 0.72-2.29
p for trend 0.75 0.89
Supplements
No 56 111 1.00 1.00
Yes 149 276 1.34 0.87-2.06 1.63 1.01-2.62
Combined food and supplements (mg)
1 (<147.5) 74 128 1.00 1.00
2 (147.5-458.6) 72 132 1.09 0.69-1.74 1.38 0.83-2.31
3 (
    >
458.7)
59 127 1.06 0.66-1.71 1.42 0.84-2.40
p for trend 0.72 0.28
    Vitamin E
Food (aTE)
1 (<7.4) 69 128 1.00 1.00
2 (7.4-11.5) 64 132 0.96 0.56-1.65 0.94 0.53-1.67
3 (
    >
11.6)
72 127 1.04 0.55-1.98 0.89 0.45-1.77
p for trend 0.84 0.89
Supplements
No 58 114 1.00 1.00
Yes 147 273 1.35 0.88-2.07 1.63 1.02-2.63
Combined food and supplements (aTE)
1 (<21.7) 69 128 1.00 1.00
2 (21.7-114.8) 88 131 1.53 0.98-2.41 1.81 1.10-1.04
3 (
    >
114.9)
48 128 0.87 0.52-1.42 1.03 0.59-1.78
p for trend 0.29 0.10
    Beta-carotene
Food (mcg)
1 (<2,070) 67 128 1.00 1.00
2 (2,070-3,675) 66 132 1.14 0.70-1.86 1.05 0.61-1.78
3 (
    >
3,676)
72 127 1.35 0.81-2.25 1.45 0.83-2.52
p for trend 0.61 0.91
Supplements
No 67 138 1.00 1.00
Yes 138 249 1.40 0.93-2.11 1.69 1.08-2.66
Combined food and supplements (mcg)
1 (<3,040) 79 128 1.00 1.00
2 (3,040-5,075) 57 132 0.82 0.51-1.33 0.87 0.52-1.47
3 (
    >
5,076)
69 127 1.09 0.67-1.79 1.38 0.80-2.35
p for trend 0.33 0.41
    Selenium
Food (mcg)
1 (<59.5) 84 128 1.00 1.00
2 (59.5-87.7) 58 132 0.48 0.28-0.81 0.55 0.31-0.98
3 (
    >
87.8)
63 127 0.40 0.21-0.78 0.41 0.20-0.85
p for trend 0.01 0.10
Supplements
No 69 148 1.00 1.00
Yes 136 239 1.44 0.95-2.15 1.64 1.05-2.56
Combined food and supplements (mcg)
1 (<72.4) 79 128 1.00 1.00
2 (72.4-103.6) 58 132 0.69 0.42-1.16 0.73 0.42-1.27
3 (
    >
103.7)
68 127 0.73 0.40-1.30 0.75 0.39-1.43
p for trend 0.20 0.30
    Lutein
Food (mcg)
1 (<1,019) 65 128 1.00 1.00
2 (1,019-1,882) 65 131 1.21 0.74-1.97 1.28 0.75-2.19
3 (
    >
1,882)
75 128 1.46 0.89-2.39 1.54 0.90-2.62
p for trend 0.63 0.51
    Lycopene
Food (mcg)
1 (<2,504) 51 127 1.00 1.00
2 (2,504-5,464) 83 133 1.68 1.01-2.79 1.43 0.83-2.47
3 (
    >
5,465)
71 127 1.58 0.91-2.74 1.48 0.82-2.68
p for trend 0.05 0.26

OR1: adjusted for age (continuous), education, race, age at menarche (continuous), menopausal status and age at menopause for postmenopausal women, parity, OC use, HRT use, BMI (continuous), tubal ligation, and total calories; OR2: further adjusted for physical activity (METs) and smoking status.

Gifkins et al.

Gifkins et al. BMC Cancer 2012 12:211   doi:10.1186/1471-2407-12-211

Open Data