Table 1

Follicular lymphoma grading according to the WHO classification1
Grading Definition
Grade 1–2 (low grade) 0–15 centroblasts per hpf*
· 1 0–5 centroblasts per hpf
· 2 6–15 centroblasts per hpf
Grade 3 >15 centroblasts per hpf
· 3A: centrocytes present
· 3B: solid sheets of centroblasts
Follicular Pattern
· Follicular >75%
· Follicular and diffuse 25–75%
· Focally follicular <25%
· Diffuse 0%**

* hpf = high-power field of 0.159 mm2.

** Diffuse areas containing >15 centroblasts per hpf are reported as DLBCL with FL (grades 1 to 2, 3A or 3B). Note that in small biopsies the absence of follicles may reflect a sampling error.

Rueda et al.

Rueda et al. BMC Cancer 2012 12:210   doi:10.1186/1471-2407-12-210

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