Table 2

Genes linked to aberrant cell proliferation
Biological Process Gene Symbol Gene Name Contrast log2 (Fold Change)
Cell cycle arrest impairment CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) M1775RvsWT −0.3066647
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha

M1775RvsWT

MutvsWT

−0.3728651
−0.3190284
SMAD3 SMAD family member 3

A1789TvsWT

M1775RvsWT

MutvsWT

−0.2675322
−0.4286813
−0.3196246
CCND1 cyclin D1 A1789TvsWT 0.3622112
PML promyelocytic leukemia M1775RvsWT −0.3045759
RUVBL1 RuvB-like 1 (E. coli) M1775RvsWT −0.3028029
TXNIP thioredoxin interacting protein A1789TvsWT −0.3985633
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 A1789TvsWT −0.2766158
Cell proliferation enhancement FOS FBJ murine osteosarcoma viral oncogene homolog

A1789TvsWT

M1775RvsWT

MutvsWT

0.4515777
0.4020256
0.4365775
DUSP1 dual specificity phosphatase 1

A1789TvsWT

M1775RvsWT

MutvsWT

0.3844494
0.7606655
0.5060076
DUSP2 dual specificity phosphatase 2 MutvsWT 0.5408689
EDN1 endothelin 1

M1775RvsWT

MutvsWT

0.4442705
0.3212824
SKP1 S-phase kinase-associated protein 1 A1789TvsWT 0.3353208
ZWILCH Zwilch, kinetochore associated, homolog (Drosophila) A1789TvsWT 0.2508541
GPR56 G protein-coupled receptor 56

A1789TvsWT

M1775RvsWT

MutvsWT

−0.3453577
−0.3310188
−0.3407359
Apoptosis blocking NFKB 1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 M1775RvsWT −0.2522979
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b M1775RvsWT −0.247568
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 M1775RvsWT −0.282513
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1 MutvsWT −0.2374774

Iofrida et al.

Iofrida et al. BMC Cancer 2012 12:207   doi:10.1186/1471-2407-12-207

Open Data