Open Access Research article

Effects on human transcriptome of mutated BRCA1 BRCT domain: A microarray study

Caterina Iofrida1, Erika Melissari1, Veronica Mariotti1, Chiara Guglielmi2, Lucia Guidugli3, Maria Adelaide Caligo2 and Silvia Pellegrini1*

Author Affiliations

1 Department of Experimental Pathology, Medical Biotechnology, Epidemiology and Infectious Diseases, University of Pisa, 56126, Pisa, Italy

2 Section of Genetic Oncology Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, 56126, Pisa, Italy

3 Laboratory of Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

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BMC Cancer 2012, 12:207  doi:10.1186/1471-2407-12-207

Published: 30 May 2012

Additional files

Additional file 1:

Microarray results of MutvsWT-contrast. The four tabs contain the DEGs, the pathway analysis results and the mapped genes by Pathway-Express and the ontological analysis results by Onto-Express, respectively.

Format: XLS Size: 3.1MB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 2:

Microarray results of M1775RvsWT-contrast. The four tabs contain the DEGs, the pathway analysis results and the mapped genes by Pathway-Express and the ontological analysis results by Onto-Express, respectively.

Format: XLS Size: 3.7MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

Microarray results of A1789TvsWT-contrast. The four tabs contain the DEGs, the pathway analysis results and the mapped genes by Pathway-Express and the ontological analysis results by Onto-Express, respectively.

Format: XLS Size: 3.3MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

Intersections among the three lists of DEGs.

Format: XLS Size: 76KB Download file

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Open Data

Additional file 5:

Intersections among the three lists of pathways.

Format: XLS Size: 36KB Download file

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Additional file 6:

Intersections among the three lists of DEGs and the list of genes related to "Cell Proliferation" biological term by Coremine.

Format: XLS Size: 342KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 7:

Intersections among the three lists of DEGs and the list of genes related to "DNA damage and repair" biological term by Coremine.

Format: XLS Size: 220KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data