CTC detection targeting human gene transcripts. Representation of tumour growth in xenografted mice. CTCs were detectable at a tumour size of 50 mm2 for all tested cell lines. CTCs out of blood samples were mostly negative for mRNA of EpCAM, MUC-1 and Her2 but showed signals for housekeeping-genes and Vimentin (MDA-MB-231, KPL-4).
Gorges et al. BMC Cancer 2012 12:178 doi:10.1186/1471-2407-12-178