Metastases and blood analysis of xenografted and tumour-free mice. No human mRNA was detectable in tissue or blood of naive mice (a). Metastatic formation was seen in all xenografts. Most of the primary tumours and metastases were positive for mRNA of EpCAM, MUC-1 and Her2 expression but downregulation of EpCAM and mainly MUC-1 was observed, as well (a-d). No signals for human tumour cells could be detected by the AdnaTest in the blood of any murine xenograft although extensive tumour vascularisation and metastatic spread was seen in these mice (a-f).
Gorges et al. BMC Cancer 2012 12:178 doi:10.1186/1471-2407-12-178