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Open Access Highly Accessed Research article

The prevalence and role of human papillomavirus genotypes in primary cervical screening in the northeast of China

Shizhuo Wang1, Heng Wei1, Ning Wang1, Shulan Zhang1*, Yao Zhang1, Qiang Ruan2, Weiguo Jiang3, Qian Xiao1, Xiaomei Luan1, Xiuyan Qian1, Lili Zhang1, Xiang Gao1 and Xiaowei Sun4

Author Affiliations

1 Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China

2 Virus Laboratory, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China

3 Department of Pathology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China

4 Division of Pediatric Neurology, Weill Cornell Medical College, New York, NY, 10065, USA

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BMC Cancer 2012, 12:160  doi:10.1186/1471-2407-12-160

Published: 1 May 2012

Abstract

Background

Studies have shown that type-specific persistence of high-risk human papillomavirus (HPV) infection contributed significantly to cervical carcinogenesis.

Methods

In this population-based study (on 24041 women), we report on the prevalent genotypes of HPVs and the prevalent genotypes of HPV persistent infection in the northeast of China.

Results

Our results showed that in HPV infected women (45.6% in total), (95% CI, 44.97%–46.23%), 17.35% (95%CI, 16.87%–17.83%) suffered persistent infection. The most common high-risk HPV types in persistent positivity were HPV-16 (18.21%; 95%CI, 17.04%–19.38%), HPV-58 (13.2%; 95%CI, 12.17%–14.23%), HPV-18 (8.66%; 95%CI, 7.81%–9.51%), HPV-52 (7.06%; 95% CI, 6.28%–7.84%) and HPV-33 (6.78%; 95% CI, 6.02%–7.54%). The prevalence of persistent infections with HPV-16,–58, −18, −52 and 33 in cervicitis were lower compared to those in CIN (all P < 0.05). HPV-58, −33 and multiple HPV persistent positivity were significantly associated with older age (all P < 0.05). HPV-18 persistent positivity was significantly associated with adenocarcinoma and lymphatic metastasis (all P < 0.05). HPV-18 persistent positivity was associated with cervical cancer prognosis (P <0.0001). Multivariate analyses showed that HPV-18 persistent positivity, (RR = 1.704, 95%CI = 1.095–2.654, p = 0.028) and lymphatic metastasis (RR = 2.304, 95%CI = 1.354–3.254, P = 0.015) were independent predictors for 3-year survival in cervical cancer.

Conclusions

we provided extensive results of HPV genotype prevalence and distribution in the northeast of China. HPV genotyping is worthwhile to perform because of its independent prognostic value in cervical cancer

Keywords:
Human papillomavirus genotype; Cervical screening; Cervical cancer; Prognosis