Table 3

Kaplan-Meier analyses and multivariate Cox's regression analyses

STS patients

OPN splice variant

n

Median values

[copies OPN splice

variant mRNA/

copies HPRT mRNA]

Kaplan-Meier analysis

multivariate Cox's regression model

Survival [months]

P

RR

P

CI


All

OPN-a low

62

0.68

90


OPN-a high

62

71

1.7

1.7

0.06

1.0-3.0


OPN-b low

62

0.49

117


OPN-b high

62

66

0.13

2.1

0.02

1.2-3.6


OPN-c low

62

0.08

94


OPN-c high

62

81

0.38

1.8

0.04

1.0-3.1


Female

OPN-a low

34

0.83

116


OPN-a high

34

53

0.08

3.0

0.01

1.3-6.8


OPN-b low

34

0.58

102


OPN-b high

34

42

0.13

3.4

< 0.01

1.4-8.2


OPN-c low

34

0.09

92


OPN-c high

34

46

0.50

2.3

0.07

0.9-5.4


RT patients

OPN-a low

26

0.65

80

OPN-a high

26

76

0.04

3.5

0.07

0.9-13.0


OPN-b low

26

0.42

147

OPN-b high

26

55

0.05

10.3

< 0.01

2.0-53.7


OPN-c low

26

0.07

147

OPN-c high

26

55

0.05

11.4

< 0.01

2.2-59.3


Association of the mRNA expression of OPN splice variants in different groups of patients (all STS patients, females and RT patients) with overall survival. The median values of OPN-a, OPN-b and OPN-c were used as cut-off points to divide the STS patients into two groups: one with high and one with low (reference group) OPN mRNA levels in tumor tissues

Hahnel et al. BMC Cancer 2012 12:131   doi:10.1186/1471-2407-12-131

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