Open Access Research article

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells

Martin Laschak1, Klaus-Dieter Spindler1, Andres J Schrader2, Andrea Hessenauer1, Wolfgang Streicher12, Mark Schrader2 and Marcus V Cronauer2*

Author Affiliations

1 Institute for General Zoology and Endocrinology, Ulm University, Albert Einstein Allee 23, 89069 Ulm, Germany

2 Department of Urology, Ulm University, Prittwitzstrasse 43, 89075, Ulm, Germany

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BMC Cancer 2012, 12:130  doi:10.1186/1471-2407-12-130

Published: 30 March 2012

Additional files

Additional file 1:

Figure 1S: JS-K does not inhibit AR-dimerization. Complementary data to experiment presented in Figure 3: AR-dimerization was determined in DU-145 cells using the CheckMate Mammalian Two-Hybrid System described in Material and Methods. Results are mean values of three independent experiments performed in quadruplicates. (DOC 20 kb).

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Additional file 2:

Figure 2S: NO does not influence hormone-induced nuclear translocation of AR-EosFP in DU-145. Complementary data to experiment presented in Figure 4. (TIFF 1541 kb).

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