Table 4

Pathological complete response relative to molecular subtypes of tumor

Tumor classification (+: yes/-: no)

Tumor response


ER/PR

HER2

Ki67

Neoadjuvant

All

pCR no

pCR yes


trastuzumab

N

%

n

%

n

%

P


Hormone receptor-positive

+

-

+

NA

176

100

162

92.0

14

8.0

0.05

+

-

-

NA

140

100

136

97.1

4

2.9

+ or -

+

+

+ or -

88

100

49

55.7

39

44.3

0.03

+ or -

+

-

+ or -

14

100

12

85.7

2

14.3

HER2-positive

+ or -

+

+ or -

+

50

100

24

48.0

26

52.0

0.03

+ or -

+

+ or -

-

52

100

37

71.2

15

28.8

Triple negative

-

-

+

NA

122

100

62

50.8

60

49.2

0.12

-

-

-

NA

7

100

6

85.7

1

14.3


All

+ or -

+ or -

+ or -

+ or -

547

100

427

78.1

120

21.9


ER, estrogen receptor; HER2, HER2/neu receptor; NA, not applicable; PR, progesterone receptor.

Fasching et al. BMC Cancer 2011 11:486   doi:10.1186/1471-2407-11-486

Open Data