Email updates

Keep up to date with the latest news and content from BMC Cancer and BioMed Central.

Open Access Highly Accessed Research article

Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment

Peter A Fasching1*, Katharina Heusinger2, Lothar Haeberle2, Melitta Niklos2, Alexander Hein2, Christian M Bayer2, Claudia Rauh2, Ruediger Schulz-Wendtland3, Mayada R Bani2, Michael Schrauder2, Laura Kahmann2, Michael P Lux2, Johanna D Strehl4, Arndt Hartmann4, Arno Dimmler5, Matthias W Beckmann2 and David L Wachter4

Author affiliations

1 Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles, California, USA

2 Department of Gynecology and Obstetrics, Erlangen University Hospital, Erlangen, Germany

3 Institute of Diagnostic Radiology, Erlangen University Hospital, Erlangen, Germany

4 Institute of Pathology, Erlangen University Hospital, Erlangen, Germany

5 Institute of Pathology, St Vincentius Hospital, Karlsruhe, Germany

For all author emails, please log on.

Citation and License

BMC Cancer 2011, 11:486  doi:10.1186/1471-2407-11-486

Published: 14 November 2011

Abstract

Background

The pathological complete response (pCR) after neoadjuvant chemotherapy is a surrogate marker for a favorable prognosis in breast cancer patients. Factors capable of predicting a pCR, such as the proliferation marker Ki67, may therefore help improve our understanding of the drug response and its effect on the prognosis. This study investigated the predictive and prognostic value of Ki67 in patients with invasive breast cancer receiving neoadjuvant treatment for breast cancer.

Methods

Ki67 was stained routinely from core biopsies in 552 patients directly after the fixation and embedding process. HER2/neu, estrogen and progesterone receptors, and grading were also assessed before treatment. These data were used to construct univariate and multivariate models for predicting pCR and prognosis. The tumors were also classified by molecular phenotype to identify subgroups in which predicting pCR and prognosis with Ki67 might be feasible.

Results

Using a cut-off value of > 13% positively stained cancer cells, Ki67 was found to be an independent predictor for pCR (OR 3.5; 95% CI, 1.4, 10.1) and for overall survival (HR 8.1; 95% CI, 3.3 to 20.4) and distant disease-free survival (HR 3.2; 95% CI, 1.8 to 5.9). The mean Ki67 value was 50.6 ± 23.4% in patients with pCR. Patients without a pCR had an average of 26.7 ± 22.9% positively stained cancer cells.

Conclusions

Ki67 has predictive and prognostic value and is a feasible marker for clinical practice. It independently improved the prediction of treatment response and prognosis in a group of breast cancer patients receiving neoadjuvant treatment. As mean Ki67 values in patients with a pCR were very high, cut-off values in a high range above which the prognosis may be better than in patients with lower Ki67 values may be hypothesized. Larger studies will be needed in order to investigate these findings further.