Table 3

Comparison of sensitivity of single and double FIT sampling for screen relevant neoplasia, at fixed specificities

Single FIT

"one of two FITs+"

"two of two FITs+"

"mean of two FITs+"


Spec

Sens

Cut-off

Sens

Cut-off

p-value

Sens

Cut-off

p-value

Sens

Cut-off

p-value


85%

51, 6%

34

53, 2%

59

1

n.a.*

n.a.*

n.a.*

53, 2%

40

1


90%

46, 0%

73

51, 6%

103

0, 07

44, 4%

27

0, 687

50, 8%

60

0, 125


95%

38, 7%

184

37, 9%

371

1

41, 1%

91

0, 453

37, 9%

159

1


Corresponding cut-off values (ng/ml) and sensitivities for screen relevant neoplasia of single FIT sampling and three different strategies of double FIT sampling at fixed specificities of 85%, 90% and 95%.

FIT = faecal immunochemical test, "one of two FITs+" = at least one of both FITs above the cut-off value, "two of two FITs+" = both FITs above the cut-off value, "mean of two FITs+" = geometric mean of both FITs above the cut-off value, spec = specificity, sens = sensitivity, cut-off = cut-off value, n.a.* = no corresponding sensitivity and cut-off value found in the range 50-200 ng/ml

Oort et al. BMC Cancer 2011 11:434   doi:10.1186/1471-2407-11-434

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