Table 5

Cumulative duration of statin use in cases and controls in 13 to 120 months prior to the index date by cancer site in cases and controls with 10 or more years of recorded data

Less than 12 months

13 to 24 months

25 to 48 months

49 to 72 months

73 months and more


cancer

Cases/Controls

Adjusted Odds ratio (95%CI) #

Cases/Controls

Adjusted Odds ratio (95%CI) #

Cases/Controls

Adjusted Odds ratio (95%CI) #

Cases/Controls

Adjusted Odds ratio (95%CI) #

Cases/Controls

Adjusted Odds ratio (95%CI)#

P-* value


breast

363/1338

1 (0.86 to 1.16)

254/962

0.96 (0.81 to 1.15)

346/1208

1.06 (0.90 to 1.25)

169/634

0.93 (0.75 to 1.15)

131/542

0.85 (0.67 to 1.08)

0.220


prostate

545/2119

0.99 (0.87 to 1.12)

489/1609

1.19 (1.04 to 1.36)

641/2424

1.06 (0.94 to 1.19)

369/1394

1.07 (0.93 to 1.24)

320/1234

1.12 (0.96 to 1.32)

0.173


colorectal

446/1527

1.06 (0.92 to 1.23)

327/1224

1.03 (0.88 to 1.21)

429/1625

0.97 (0.84 to 1.13)

285/902

1.20 (1.01 to 1.43)

213/711

1.21 (0.99 to 1.48)

0.069


lung

419/1375

1.06 (0.91 to 1.25)

342/1064

1.21 (1.01 to 1.43)

458/1586

1.05 (0.89 to 1.23)

259/950

1.00 (0.82 to 1.21)

235/734

1.17 (0.95 to 1.45)

0.240


blood

202/821

0.72 (0.59 to 0.88)

160/616

0.8 (0.64 to 1.00)

233/966

0.74 (0.61 to 0.89)

133/468

0.87 (0.68 to 1.11)

90/428

0.55 (0.41 to 0.73)

< 0.001


bladder

172/565

1.14 (0.91 to 1.43)

137/456

1.19 (0.93 to 1.53)

190/681

1.01 (0.81 to 1.26)

117/360

1.19 (0.91 to 1.57)

94/280

1.37 (1.02 to 1.86)

0.062


skin

110/312

1.41 (1.04 to 1.89)

56/270

0.79 (0.55 to 1.13)

112/349

1.21 (0.89 to 1.64)

50/176

0.87 (0.56 to 1.36)

56/185

1.04 (0.70 to 1.55)

0.626


oesophagus

103/409

0.9 (0.67 to 1.20)

75/272

1.01 (0.72 to 1.42)

105/445

0.81 (0.61 to 1.09)

68/248

1.09 (0.77 to 1.55)

59/185

1.03 (0.70 to 1.52)

0.870


pancreas

76/277

0.89 (0.63 to 1.24)

61/196

1.22 (0.84 to 1.78)

86/286

0.99 (0.71 to 1.38)

50/172

1.04 (0.69 to 1.56)

40/148

0.85 (0.53 to 1.37)

0.475


stomach

58/232

0.84 (0.58 to 1.22)

60/206

0.82 (0.56 to 1.19)

77/301

0.86 (0.61 to 1.21)

35/150

0.56 (0.35 to 0.90)

38/165

0.63 (0.39 to 1.00)

0.008


All cancers

2890/10413

0.99 (0.94 to 1.05)

2303/8005

1.05 (0.99 to 1.11)

3107/11437

0.98 (0.93 to 1.03)

1776/6319

1.01 (0.95 to 1.08)

1462/5259

1.02 (0.95 to 1.10)

0.958


# Adjusted for Townsend quintile, body mass index, smoking status, myocardial infarction, coronary heart disease, diabetes, hypertension, stroke, rheumatoid arthritis, use of NSAIDs, Cox2-inhibitors, aspirin

† Also adjusted for family history of breast cancer, benign breast disease, use of oral contraceptives, hormone-replace therapy

‡ Also adjusted for colitis and Crohn's disease

* Trend test based on number of months prescribed

Vinogradova et al. BMC Cancer 2011 11:409   doi:10.1186/1471-2407-11-409

Open Data