Table 2

Use of statins in cases and controls in 13 to 72 months prior the index date by cancer site (in cases and matched controls with at least 6 years of medical records)

Cancer

Total number of cases

Total number of controls

N of statin users in cases (%)

N of statin users in controls (%)

Unadjusted OR (95%CI)

Adjusted# OR (95%CI)

P-value


breast

15666

62938

1481 (9.5)

6227 (9.9)

0.98

(0.92 to 1.04)

1.00

(0.93 to 1.08)

0.993


prostate

14764

61853

2774 (18.8)

11508 (18.6)

1.03

(0.98 to 1.08)

1.08

(1.01 to 1.14)

0.016


colorectal

11749

48624

2000 (17.0)

7770 (16.0)

1.12

(1.06 to 1.19)

1.07

(1.00 to 1.15)

0.056


lung

10163

42415

1998 (19.7)

7621 (18.0)

1.16

(1.09 to 1.23)

1.07

(0.99 to 1.16)

0.095


blood

7185

29162

973 (13.5)

4339 (14.9)

0.91

(0.84 to 0.99)

0.78

(0.71 to 0.86)

< 0.001


bladder

4227

17559

856 (20.3)

3125 (17.8)

1.23

(1.12 to 1.34)

1.15

(1.03 to 1.29)

0.012


skin

3249

13115

433 (13.3)

1675 (12.8)

1.12

(0.99 to 1.26)

1.08

(0.93 to 1.26)

0.292


oesophagus

3159

13041

496 (15.7)

2106 (16.1)

0.97

(0.87 to 1.09)

0.88

(0.77 to 1.01)

0.072


pancreas

2110

8762

365 (17.3)

1397 (15.9)

1.15

(1.01 to 1.32)

0.96

(0.82 to 1.14)

0.671


stomach

1992

8279

322 (16.2)

1363 (16.5)

1.00

(0.87 to 1.16)

0.86

(0.72 to 1.02)

0.078


All cancers

88125

362254

13621 (15.5)

54606 (15.1)

1.07

(1.05 to 1.09)

1.01

(0.99 to 1.04)

0.280


# Adjusted for Townsend quintile, body mass index, smoking status, myocardial infarction, coronary heart disease, diabetes, hypertension, stroke, rheumatoid arthritis, use of NSAIDs, Cox2-inhibitors, aspirin

† Also adjusted for family history of breast cancer, use of oral contraceptives, hormone-replace therapy

‡ Also adjusted for colitis and Crohn's disease

Vinogradova et al. BMC Cancer 2011 11:409   doi:10.1186/1471-2407-11-409

Open Data