Ketogenic diet fed ad libitum does not prolong survival in the LNT-229 xenograft model. (A) Mice carrying LNT-229 xenografts were fed with ketogenic or control diet, observed in daily intervals and killed at the onset of neurological symptoms equal or worse than grade 2 (Kaplan-Meier survival estimate, Mantel-Cox log-rank p = 0.288). On days 37 and 65, magnetic resonance imaging of three randomly chosen animals from each group was performed. Representative images (day 65) are depicted. (B) Tumors of mice fed the ketogenic diet displayed proliferation (Ki-67 labeling) indices similar to those of control animals (mean and standard error of the mean, Student's t-test p = 0.637).
Maurer et al. BMC Cancer 2011 11:315 doi:10.1186/1471-2407-11-315