Open Access Highly Accessed Research article

Nottingham Prognostic Index in Triple-Negative Breast Cancer: a reliable prognostic tool?

André Albergaria1, Sara Ricardo12, Fernanda Milanezi1, Vítor Carneiro3, Isabel Amendoeira4, Daniella Vieira5, Jorge Cameselle-Teijeiro6 and Fernando Schmitt14*

Author Affiliations

1 Institute of Molecular Pathology and Immunology of Porto University (IPATIMUP), Porto, Portugal

2 Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal

3 Department of Pathology of Hospital of Divino Espírito Santo, Ponta Delgada, Portugal

4 Department of Pathology, Medical Faculty of University of Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal

5 Federal University of Santa Catarina, Florianopolis, Brazil

6 Department of Pathology, Hospital Xeral-Cíes, Vigo, Spain

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BMC Cancer 2011, 11:299  doi:10.1186/1471-2407-11-299

Published: 15 July 2011

Additional files

Additional file 1:

Association of tumour size (A), histological grade (B) and lymph node status (C) to high scores of NPI in TNBC. The boxplot graphic show an association between larger tumours, displaying high histological grade and with extensive lymph node invasion, with tumours clustered into the worst outcome group, represented by NPI > 5.4 (p < 0.0001) (A, B and C). The graphic highlights the contribution of lymph node status to the augmentation of NPI, showing that LNS is a determinant factor to predict worse prognosis in TNBC patients.

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