Nottingham Prognostic Index in Triple-Negative Breast Cancer: a reliable prognostic tool?
1 Institute of Molecular Pathology and Immunology of Porto University (IPATIMUP), Porto, Portugal
2 Institute of Biomedical Sciences of Abel Salazar (ICBAS), Porto, Portugal
3 Department of Pathology of Hospital of Divino Espírito Santo, Ponta Delgada, Portugal
4 Department of Pathology, Medical Faculty of University of Porto, Alameda Prof. Hernâni Monteiro, Porto, Portugal
5 Federal University of Santa Catarina, Florianopolis, Brazil
6 Department of Pathology, Hospital Xeral-Cíes, Vigo, Spain
BMC Cancer 2011, 11:299 doi:10.1186/1471-2407-11-299Published: 15 July 2011
Additional file 1:
Association of tumour size (A), histological grade (B) and lymph node status (C) to high scores of NPI in TNBC. The boxplot graphic show an association between larger tumours, displaying high histological grade and with extensive lymph node invasion, with tumours clustered into the worst outcome group, represented by NPI > 5.4 (p < 0.0001) (A, B and C). The graphic highlights the contribution of lymph node status to the augmentation of NPI, showing that LNS is a determinant factor to predict worse prognosis in TNBC patients.
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