Table 1

Five AQPs were identified to be deregulated (* p-value < 0.05; Fold change ≥ 2 or ≤ 0.5) in tumors versus normal tissues, or in AC versus SCC subtype across different microarray studies

AQP isoform

Microarray Data

qRT-PCR Data

Median Ct value in tissues

Pearson correlation of AQPs


Tumor vs Normal Fold change

AC vs SCC Fold change

Tumor vs Normal Fold change

AC vs SCC Fold change

AQP1

AQP3

AQP4

AQP5


AQP1

0.18*

7.5*

0.22*

2.36*

27.8

X

x

x

x


AQP3

1.00

4.8*

0.93

5.81*

26.9

0.46

x

x

x


AQP4

0.16*

2.8*

0.11*

5.96*

28.7

0.82

0.42

x

x


AQP5

0.94

6.9*

0.50*

1.88

31.8

0.31

0.40

0.24

x


AQP9

0.26*

0.91

1.05

0.64

31.0

0.39

0.34

0.30

0.10


The results were mainly confirmed by qRT-PCR including information about expression range in all tissues and Pearson correlation between different AQPs.

AQP: aquaporin; AC: adenocarcinoma; SCC: squamous cell carcinoma; fold change was calculated across microarray datasets (median); fold change in bold and marked (*) indicates statistical significance (p-value < 0.05).

Warth et al. BMC Cancer 2011 11:161   doi:10.1186/1471-2407-11-161

Open Data