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Open Access Case report

Seminal vesicle metastasis after partial hepatectomy for hepatocellular carcinoma

Li Gong1, Minwen Zheng2, Yanhong Li1, Wendong Zhang1, Wangjun Bu3, Lifang Shi4, Wei Zhang1* and Hong Yan5*

Author Affiliations

1 The Helmholtz Sino-German Laboratory for Cancer Research, Department of Pathology, Tangdu Hospital, the Fourth Military Medical University, 710038 Xi'an, Shaanxi Province, PR China

2 Department of Radiology, Xijing Hospital, the Fourth Military Medical University, 710032 Xi'an, Shaanxi Province, PR China

3 Department of General Surgery, the Second Affiliated Hospital, Xi'an Jiaotong University, 710031 Xi'an, Shaanxi Province, PR China

4 Department of Radiology, the Second Affiliated Hospital, Xi'an Jiaotong University, 710031 Xi'an, Shaanxi Province, PR China

5 Depatment of Ophthalmology, Tangdu Hospital, the Fourth Military Medical University, 710038 Xi'an, Shaanxi Province, PR China

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BMC Cancer 2011, 11:111  doi:10.1186/1471-2407-11-111

Published: 28 March 2011

Abstract

Background

Metastasis to the seminal vesicle is extremely rare for hepatocellular carcinoma (HCC). To our knowledge, it has been not reported in literature. The purpose of the present paper was to report a case of metastasis to the seminal vesicle after HCC resection, along with its histological features and immunohistochemical characteristics.

Case Presentation

A 46-year-old Chinese man was admitted to our hospital due to abdominal distension. He had a history of HCC related to hepatitis B virus infection. Moreover, left partial hepatectomy was performed in another hospital 28 months ago, and right partial hepatectomy for HCC recurrence in our hospital 4 months ago. After resection, radiofrequency ablation therapy had been performed. About 27 months after the initial operation, contrast-enhanced computed tomography (CT) of the pelvic cavity revealed a mass with homogeneous enhancement in the seminal vesicle. Transrectal needle biopsy revealed a poorly differentiated adenocarcinoma. Therefore, seminal vesiculectomy was resected. The histological diagnosis of the removed tumor was compatible with the original HCC. Immunohistochemical examination demonstrated that the tumor cells were positive for glypican-3 (GPC3), alpha-fetoprotein (AFP), hepatocyte paraffin-1 (Hep Par 1), cytokeratin 18 (CK 18), and hepatocyte antigen, which confirmed that the seminal vesicle tumor was a metastatic tumor of HCC. However, CT subsequently revealed multiple metastatic foci in the abdominal and pelvic cavities in May 2009 and August 2009, respectively.

Conclusion

The seminal vesicle is an extremely rare metastatic site for HCC, and the prognosis is very poor. A combination of clinical and pathological features is necessary for a correct diagnosis, and primary tumor should be excluded before diagnosing metastatic foci.

Keywords:
seminal vesicle; hepatocellular carcinoma; metastasis; clinical pathology