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Open Access Highly Accessed Research article

Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer

Oscar Fernández-Guinea12, Alejandro Andicoechea13, Luis O González145, Salomé González-Reyes15, Antonio M Merino6, Luis C Hernández7, Alfonso López-Muñiz7, Paz García-Pravia2 and Francisco J Vizoso135*

Author Affiliations

1 Unidad de Investigación, Hospital de Jove, Gijón-Spain

2 Servicio de Radiodiagnóstico, Hospital de Jove, Gijón-Spain

3 Servicio de Cirugía General, Hospital de Jove, Gijón-Spain

4 Servicio de Anatomía Patológica, Hospital de Jove, Gijón-Spain

5 Instituto Universitario de Oncología del Principado de Asturias, Oviedo-Spain

6 Servicio de Anatomía Patológica, Hospital de Cabueñes, Gijón-Spain

7 Departamento de Morfología y Biología Celular, Universidad de Oviedo-Spain

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BMC Cancer 2010, 10:8  doi:10.1186/1471-2407-10-8

Published: 8 January 2010

Abstract

Background

To investigate the relationship between the magnetic resonance imaging (MRI) features of breast cancer and its clinicopathological and biological factors.

Methods

Dynamic MRI parameters of 68 invasive breast carcinomas were investigated. We also analyzed microvessel density (MVD), estrogen and progesterone receptor status, and expression of p53, HER2, ki67, VEGFR-1 and 2.

Results

Homogeneous enhancement was significantly associated with smaller tumor size (T1: < 2 cm) (p = 0.015). Tumors with irregular or spiculated margins had a significantly higher MVD than tumors with smooth margins (p = 0.038). Tumors showing a maximum enhancement peak at two minutes, or longer, after injecting the contrast, had a significantly higher MVD count than those which reached this point sooner (p = 0.012). The percentage of tumors with vascular invasion or high mitotic index was significantly higher among those showing a low percentage (≤ 150%) of maximum enhancement before two minutes than among those ones showing a high percentage (>150%) of enhancement rate (p = 0.016 and p = 0.03, respectively). However, there was a significant and positive association between the mitotic index and the peak of maximum intensity (p = 0.036). Peritumor inflammation was significantly associated with washout curve type III (p = 0.042).

Conclusions

Variations in the early phase of dynamic MRI seem to be associated with parameters indicatives of tumor aggressiveness in breast cancer.