Table 3

Relation of HAX1 expression to breast cancer prognostic factors

Characteristic

n

HAX1 (I) expression:

HAX1 (II) expression:

median of relative over-

expression (lower and

upper quartile values)

median of relative over-

expression (lower and

upper quartile values)


Size (cm)

< 2

5

0.82 (0.35-1.30)

0.82 (0.41-2.04)

> 2

10

2.2 (1.38-4.15)*

2.99 (1.70-7.5)*


Nodal status

Positive

9

1.3 (1.54-4.15)

1.7 (0.82-2.90)

Negative

6

2.35 (0.82-2.18)

4.05 (2.04-7.75)*


Histology

Ductal

7

1.3 (0.36-2.23)

2.04 (0.41-3.34)

Lobular

3

1.38 (1.33-2.83)

2.62 (1.54-5.50)

Papillary

4

3.77 (2.03-7.10)

6.81 (1.87-14.46)

Mixed

1

1.08

1.7


Grade

1

3

1.3 (0.36-1.54)

2.04 (0.41-2.89)

2

9

1.88 (1.08-2.83)

2.62 (1.09-5.48)

3

2

3.17 (2.18-4.15)

5.2 (2.65-7.75)


ER status

Positive

9

1.33 (1.08-1.54)

2.04 (1.55-2.89)

Negative

6

2.51 (1.88-4.15)

4.06 (1.09-7.75)


PR status

Positive

8

1.32 (0.95-1.46)

1.9 (1.18-2.76)

Negative

7

2.23 (1.88-4.15)

3.34 (1.09-7.75)*


HER2 status

Positive

7

1.30 (0.82-1.54)

1.7 (0.82-2.89)

Negative

8

2.51 (1.63-4.75)

4.06 (1.86-9.36)*


* denotes a P-value of < 0.005

Relationship between the expression of the HAX1 splice variants I and II and established prognostic factors in breast cancer. Median of relative overexpression was calculated for each group (lower and upper quartile values in parenthesis). Statistical significance was denoted in the groups were the number of cases was sufficient to perform the Wilcoxon matched-pairs test (size, nodal status, ER, PR, HER2 status) and a P-value of < 0.05 was observed.

Trebinska et al. BMC Cancer 2010 10:76   doi:10.1186/1471-2407-10-76

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