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Open Access Highly Accessed Research article

Preoperative dexamethasone reduces postoperative pain, nausea and vomiting following mastectomy for breast cancer

Jorge Gómez-Hernández1, Alba Lorena Orozco-Alatorre1, Marisela Domínguez-Contreras1, Antonio Oceguera-Villanueva1, Salvador Gómez-Romo1, Andrea Socorro Alvarez Villaseñor2, Clotilde Fuentes-Orozco2 and Alejandro González-Ojeda2*

Author Affiliations

1 Breast Tumor Clinic. Oncologic Institute of Jalisco, Health Secretary. Calle Coronel Calderon 715, Colonia El Retiro. Postal code 44280, Guadalajara, Jalisco. México

2 Research Unit in Clinical Epidemiology, Specialties Hospital, Western Medical Center. Mexican Institute of Social Security. Avenida Belisario Domínguez 1000, Colonia Independencia. Postal code 44340, Guadalajara, Jalisco. México

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BMC Cancer 2010, 10:692  doi:10.1186/1471-2407-10-692

Published: 23 December 2010

Abstract

Background

Dexamethasone has been reported to reduce postoperative symptoms after different surgical procedures. We evaluated the efficacy of preoperative dexamethasone in ameliorating postoperative nausea and vomiting (PONV), and pain after mastectomy.

Methods

In this prospective, double-blind, placebo-controlled study, 70 patients scheduled for mastectomy with axillary lymph node dissection were analyzed after randomization to treatment with 8 mg intravenous dexamethasone (n = 35) or placebo (n = 35). All patients underwent standardized procedures for general anesthesia and surgery. Episodes of PONV and pain score were recorded on a visual analogue scale. Analgesic and antiemetic requirements were also recorded.

Results

Demographic and medical variables were similar between groups. The incidence of PONV was lower in the dexamethasone group at the early postoperative evaluation (28.6% vs. 60%; p = 0.02) and at 6 h (17.2% vs. 45.8%; p = 0.03). More patients in the placebo group required additional antiemetic medication (21 vs. 8; p = 0.01). Dexamethasone treatment significantly reduced postoperative pain just after surgery (VAS score, 4.54 ± 1.55 vs. 5.83 ± 2.00; p = 0.004), at 6 h (3.03 ± 1.20 vs. 4.17 ± 1.24; p < 0.0005) and at 12 h (2.09 ± 0.85 vs. 2.54 ± 0.98; p = 0.04). Analgesics were required in more patients of the control group (21 vs. 10; p = 0.008). There were no adverse events, morbidity or mortality.

Conclusions

Preoperative intravenous dexamethasone (8 mg) can significantly reduce the incidence of PONV and pain in patients undergoing mastectomy with axillary dissection for breast cancer.

Trial registration number

NCT01116713