Kaplan-Meier plots of disease-free (A-C) and overall (D-F) survival in primary resected Barrett's cancer patients according to CD3+ (A and D), CD8+ (B and E), and CD45RO+ (C and F) tumor infiltrating lymphocytes (TILs). In each cohort high and low TIL densities were plotted according to the corresponding cut-off values. Blue lines indicate patients with tumors containing high TIL densities, red lines indicate patients whose tumors had low densities of TILs. P values are calculated by log-rank tests. The 5-year disease-free survival (DFS) rate for patients with high CD3+ levels was 49.2% compared to 23.6% for patients with low levels of CD3+ TILs (overall survival (OS): 54.7% versus 29.7%). Patients with high densities of CD45RO+ TILs had a 5-year DFS rate of 45.7% in contrast to 14.9% for patients with low densities of CD45RO+ (OS: 47.9% versus 24.4%).
Rauser et al. BMC Cancer 2010 10:608 doi:10.1186/1471-2407-10-608