Table 2

TGFBR2, BAX, IGF2R, MSH3, MSH6 microsatellite sequences, BRAF and KRAS mutation frequency and MLH1 promoter hypermethylation status in the MSI-H colorectal cancer according to the large bowel of origin (rectal/sigmoid carcinomas compared with those located elsewhere in the colon from both series)

Tumor location

TGFBR2

(%)

BAX

(%)

IGF2R

(%)

MSH3

(%)

MSH6

(%)

MLH1 methylation

(%)

KRAS

(%)

BRAF

(%)


Proximal Colon

23/26 (88)

12/26 (46)

8/26 (31)

20/26 (77)

5/26 (19)

10/19 (53)

5/26 (19)

9/21 (43)

Rectum/Sigmoid

4/16 (25)

3/16 (19)

3/16 (19)

0/16 (0)

1/16 (6)

0/12 (0)

4/16 (25)

2/12 (17)

P = 0.00005

P = 0.102

P = 0.485

P = 0.0000005

P = 0.380

P = 0.004

P = 0.711

P = 0.249


MSI-H - microsatellite instability-high

Pinheiro et al. BMC Cancer 2010 10:587   doi:10.1186/1471-2407-10-587

Open Data