Open Access Research article

Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin

Manuela Pinheiro1, Terje Ahlquist23, Stine A Danielsen23, Guro E Lind23, Isabel Veiga1, Carla Pinto1, Vera Costa1, Luís Afonso4, Olga Sousa5, Maria Fragoso6, Lúcio Santos7, Rui Henrique49, Paula Lopes4, Carlos Lopes49, Ragnhild A Lothe238 and Manuel R Teixeira139*

Author Affiliations

1 Department of Genetics, Portuguese Oncology Institute - Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal

2 Department of Cancer Prevention, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0310 Oslo, Norway

3 Centre for Cancer Biomedicine, University of Oslo, Montebello, 0310 Oslo, Norway

4 Department of Pathology, Portuguese Oncology Institute - Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal

5 Department of Radiotherapy, Portuguese Oncology Institute - Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal

6 Department of Oncology, Portuguese Oncology Institute - Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal

7 Department of Surgery, Portuguese Oncology Institute - Porto, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal

8 Faculty of Medicine, University of Oslo, Oslo, Norway

9 Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Largo Prof. Abel Salazar, 4099-003 Porto, Portugal

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BMC Cancer 2010, 10:587  doi:10.1186/1471-2407-10-587

Published: 27 October 2010

Additional files

Additional file 1:

Clinical and genetic parameters evaluated in the MSI-H tumors according to the large bowel site of origin. Table presenting the clinical and genetic parameters evaluated in the MSI-H tumors enrolled in this study.

Format: DOC Size: 147KB Download file

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Additional file 2:

Somatic mutations detected in KRAS exon 2 in rectal and sigmoid cancer patients from the test series. Table showing the somatic mutations detected in KRAS exon 2 in rectal and sigmoid cancer patients from the test series.

Format: DOC Size: 29KB Download file

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Open Data