Table 2

Association of rs7566605 with BMI and BC risk.

rs7566605

CC

GC

GG

P-values


Cases

562

572

135

Controls

944

1,008

242

OR a (BC risk)

1

0.95 (0.82-1.10)

0.93 (0.74-1.19)

0.466c


Normal weight (BMI <25)

797

862

208

Overweight (BMI <30)

656

624

143

Obese (BMI ≥30)

295

308

80

BMIb

26.08 (25.87-26.30)

26.00 (25.78-26.21)

26.05 (25.62-26.48)

0.697c

OR overweight or obesed

1

0.90 (0.79-1.03)

0.88 (0.71-1.08)

0.104c

OR obesed

1

0.95 (0.79-1.15)

1.00 (0.75-1.34)

0.823c


aOR: odds ratio for BC risk from conditional logistic regression analysis on matched data; cases of carcinoma in situ and their controls were excluded from the analysis, the C allele was taken as reference.

bBody Mass Index. Adjusted for age and case-control status; cases of carcinoma in situ and their controls were included in the analysis, mean (5th - 95th percentiles)

cP test of trend

dOR: odds ratio from unconditional logistic regression comparing this outcome to normal weight, adjusted for age and case-control-status. The C allele was taken as reference.

Campa et al. BMC Cancer 2010 10:563   doi:10.1186/1471-2407-10-563

Open Data