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Open Access Research article

Hyperbolastic modeling of tumor growth with a combined treatment of iodoacetate and dimethylsulphoxide

Wayne M Eby1*, Mohammad A Tabatabai1 and Zoran Bursac2

Author Affiliations

1 Department of Mathematical Sciences, Cameron University, 2800 W Gore Blvd, Lawton, OK 73505, USA

2 Department of Biostatistics, University of Arkansas for Medical Sciences, Slot 820, Little Rock, AR 72205, USA

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BMC Cancer 2010, 10:509  doi:10.1186/1471-2407-10-509

Published: 23 September 2010

Abstract

Background

An understanding of growth dynamics of tumors is important in understanding progression of cancer and designing appropriate treatment strategies. We perform a comparative study of the hyperbolastic growth models with the Weibull and Gompertz models, which are prevalently used in the field of tumor growth.

Methods

The hyperbolastic growth models H1, H2, and H3 are applied to growth of solid Ehrlich carcinoma under several different treatments. These are compared with results from Gompertz and Weibull models for the combined treatment.

Results

The growth dynamics of the solid Ehrlich carcinoma with the combined treatment are studied using models H1, H2, and H3, and the models are highly accurate in representing the growth. The growth dynamics are also compared with the untreated tumor, the tumor treated with only iodoacetate, and the tumor treated with only dimethylsulfoxide, and the combined treatment.

Conclusions

The hyperbolastic models prove to be effective in representing and analyzing the growth dynamics of the solid Ehrlich carcinoma. These models are more precise than Gompertz and Weibull and show less error for this data set. The precision of H3 allows for its use in a comparative analysis of tumor growth rates between the various treatments.