TStrC modulate immunophenotype of NK cells. Phenotyping of NK cells cocultured with TStrC for four days in the presence of 100 U/ml IL-2. For control IL-2 stimulated NK cells were cultured without TStrC for four days. The cocultured NK cells displayed a significantly reduced expression of the activating receptors NKp44 and NKp46 (p < 0,01), as well as CD56 (p < 0,05). Remarkably, the expression of the activation marker CD69 and of the inhibitory receptor NKG2A remained unaffected (n = 3).
Johann et al. BMC Cancer 2010 10:501 doi:10.1186/1471-2407-10-501