Table 1

Comparison of positive rates of CpG, TpG, TpA (deamination on the antisense strand), and other kinds of mutations at each CpG site between 4 normal gastric biopsies (Normal) and 5 pairs of gastric carcinoma tissues (GC) and the corresponding normal tissues (GC-Nor) (mean ± SD, %)

CpG site

CpG

TpG

TpAa

Others


Normal

GC-Nor

GC

Normal

GC-Nor

GC

Normal

GC-Nor

GC

Normal

GC-Nor

GC


A

32.8 ± 9.9

28.7 ± 8.0

29.8 ± 8.8

32.6 ± 9.0

32.4 ± 7.7

33.5 ± 6.4

27.7 ± 2.7

30.1 ± 6.2

30.7 ± 6.3

7.0 ± 7.0

8.7 ± 5.9

6.0 ± 4.0

B

22.0 ± 3.3

23.7 ± 6.8

24.5 ± 10.1

36.1 ± 5.1

30.8 ± 18.1

28.0 ± 6.1

29.3 ± 3.8

32.2 ± 7.3

35.4 ± 6.1

12.6 ± 1.4

13.4 ± 6.4

12.1 ± 8.6

C

22.5 ± 9.2

21.2 ± 4.0

22.0 ± 11.6

44.3 ± 7.8

43.2 ± 7.4

46.8 ± 7.6

19.7 ± 14.2

28.6 ± 9.3

22.2 ± 9.0

13.5 ± 2.9

7.1 ± 2.3b

8.9 ± 5.5

D

25.4 ± 12.3

29.7 ± 8.6

30.3 ± 10.8

34.8 ± 11.1

29.0 ± 6.0

42.6 ± 15.1

31.1 ± 13.0

26.0 ± 8.6

22.9 ± 6.1

8.7 ± 2.2

15.3 ± 6.3

4.1 ± 2.6c

E

19.9 ± 9.6

30.2 ± 6.6

27.4 ± 6.6

35.1 ± 9.6

31.0 ± +7.4

34.9 ± 5.0

42.0 ± 11.3

34.3 ± 6.2

30.5 ± 4.7

3.0 ± 2.4

4.5 ± 4.0

7.3 ± 3.2

F

17.9 ± 4.7

24.9 ± 7.3

21.6 ± 5.4

38.7 ± 0.2

39.2 ± 9.3

48.4 ± 8.0

36.9 ± 1.4

33.8 ± 8.1

27.2 ± 5.7

6.5 ± 4.6

2.0 ± 1.5

2.8 ± 1.7

G

24.3 ± 7.4

24.2 ± 4.1

33.9 ± 5.8

30.5 ± 8.1

31.7 ± 4.6

29.4 ± 5.0

38.5 ± 2.2

33.8 ± 10.6

27.9 ± 6.1

6.7 ± 6.4

10.3 ± 6.7

8.7 ± 5.7

H

22.1 ± 13.4

20.0 ± 6.5

21.8 ± 5.3

32.3 ± 14.5

32.7 ± 12.8

32.1 ± 6.8

34.2 ± 11.1

39.3 ± 8.3

39.4 ± 11.8

11.5 ± 8.2

7.9 ± 3.2

6.7 ± 3.0

I

9.4 ± 5.2

7.1 ± 4.7

8.6 ± 4.6

11.3 ± 5.5

15.4 ± 7.3

13.7 ± 3.6

36.1 ± 11.1

31.2 ± 9.9

27.7 ± 10.0

43.1 ± 14.6

46.2 ± 6.9

49.9 ± 7.1

J

18.3 ± 8.2

20.6 ± 3.0

20.2 ± 12.6

39.9 ± 5.9

38.3 ± 6.8

41.3 ± 15.7

32.6 ± 7.8

28.8 ± 5.7

30.1 ± 8.7

9.1 ± 5.9

12.3 ± 5.0

8.4 ± 4.7

K

22.9 ± 10.0

23.3 ± 2.8

21.6 ± 7.0

39.5 ± 7.1

43.2 ± 4.1

37.2 ± 12.5

24.2 ± 7.5

24.2 ± 5.6

30.8 ± 14.9

13.4 ± 6.5

9.3 ± 3.7

10.3 ± 2.4

L

22.8 ± 1.4

14.8 ± 4.6d

20.0 ± 9.4

24.1 ± 12.6

27.9 ± 15.0

20.7 ± 2.1

26.9 ± 13.2

19.4 ± 11.8

25.4 ± 4.4

26.2 ± 6.4

37.9 ± 27.6

33.9 ± 8.0

M

27.4 ± 7.3

21.6 ± 8.4

22.8 ± 4.6

39.6 ± 7.0

36.4 ± 7.7

35.5 ± 12.7

30.8 ± 4.0

34.7 ± 8.4

34.4 ± 7.0

2.2 ± 5.0

7.4 ± 5.8

7.3 ± 5.5

N

27.7 ± 4.3

27.2 ± 9.5

35.3 ± 7.7

31.4 ± 4.0

27.2 ± 7.6

22.3 ± 8.2

35.0 ± 8.9

33.4 ± 9.9

30.9 ± 4.9

5.9 ± 7.1

12.2 ± 6.4

11.5 ± 2.7

O

28.4 ± 7.8

32.2 ± 9.2

32.9 ± 8.8

37.2 ± 11.9

23.4 ± 7.0

33.6 ± 6.5

22.6 ± 11.5

34.4 ± 10.6e

24.3 ± 3.4

11.8 ± 5.5

9.9 ± 6.1

9.3 ± 4.7

P

20.1 ± 6.5

21.3 ± 4.2

22.7 ± 7.3

32.5 ± 16.0

35.7 ± 3.6

37.0 ± 11.7

33.1 ± 12.7

27.8 ± 9.8

27.0 ± 5.8

14.3 ± 6.4

15.2 ± 10.3

13.3 ± 5.2

Q

21.8 ± 8.9

24.8 ± 10.5

21.9 ± 6.9

40.8 ± 4.7

41.5 ± 7.6

44.6 ± 9.2

27.8 ± 6.0

26.2 ± 6.7

26.9 ± 10.7

9.6 ± 5.8

7.4 ± 4.6

6.6 ± 3.2


Mean

22.7 ± 7.6

23.3 ± 6.4

24.6 ± 7.8

34.2 ± 7.6

32.9 ± 7.3

34.2 ± 9.4

31.1 ± 5.9

30.5+4.8

29.0 ± 4.5

12.1 ± 9.7

13.4 ± 11.5

12.2 ± 11.9


(Total)

(23.6 ± 7.6)

(33.8 ± 8.0)

(30.2 ± 5.1)

(12.5 ± 10.8)


a representation of deamination on the antisense strand; b Normal vs. GC-Nor, p = 0.022; c GC vs. GC-Nor, p = 0.015; d/e Normal vs. GC-Nor, p = 0.022/0.046

Xiang et al. BMC Cancer 2010 10:44   doi:10.1186/1471-2407-10-44

Open Data