Cytotoxic effects of 5-FU and the expression of p-AKT by drug treatment in cells transfected with LMP2A siRNA. (A) LMP2A siRNA-silenced SNU-719 cells were subjected to RT-PCR for LMP2A in a time-dependent manner. (B) The inhibitory effects on cellular proliferation caused by 5-FU treatment were more pronounced in SNU-719 cells transfected with LMP2A siRNA than in cells transfected with the scrambled siRNA. (C) The expression of p-AKT was reduced further by 5-FU in cells transfected with LMP2A siRNA compared with in cells transfected with the scrambled siRNA (NC).
Shin et al. BMC Cancer 2010 10:425 doi:10.1186/1471-2407-10-425