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Open Access Highly Accessed Research article

Relationship between H.Pylori infection and clinicopathological features and prognosis of gastric cancer

Hai-Bo Qiu12, Li-Yi Zhang3, Rajiv-Prasad Keshari12, Guo-Qiang Wang12, Zhi-Wei Zhou12*, Da-Zhi Xu12, Wei Wang12, You-Qin Zhan12 and Wei Li12

Author Affiliations

1 State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China

2 Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, PR China

3 Department of Clinical Oncology, The University of HongKong, HongKong

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BMC Cancer 2010, 10:374  doi:10.1186/1471-2407-10-374

Published: 17 July 2010

Abstract

Background

Aimed to assess the relationship between H.Pylori and the clinicopathological features and prognosis of gastric cancer by quantitative detection of H.Pylori.

Methods

157 patients were enrolled, all patients had a record of clinicopathological parameters. Specimens including the tumor and non-neoplastic were detected for H.Pylori by Real-Time PCR and analyzed clinical data retrospectively. Variables independently affecting prognosis were investigated by means of multivariate analysis using the Cox proportional hazards model.

Results

H.Pylori infection was greater in non-neoplastic tissue than the tumor tissue (p < 0.05), H.Pylori infection and its copies were related to the tumor site and N staging (p < 0.05). Overall survival (OS) in all 157 patients has no correlation with the H.Pylori infection status (p = 0.715). As to the patients who underwent a curative surgery, relapse-free survival (RFS) has no correlation with the H.Pylori infection status (p = 0.639). Among the H.Pylori positive patients, OS and RFS of those with higher copies were longer than in patients with low copies, but there was no significant statistical difference.

Conclusions

H.Pylori infection status and its copies were related to N staging. The OS and RFS in patients with positive H.Pylori status has no significant difference from the patients with negative H.Pylori status.