Table 1

C26 induces muscle wasting

TREATMENT

MUSCLE


Soleus

EDL

Tibialis


Control (weight, g)

6.3 ± 0.2

12.5 ± 0.4

42.7 ± 2.4

C26 (weight, g)

4.9 ± 0.1 *

9.7 ± 0.3 *

30.5 ± 0.9 *

C26 (weight, % of control)

77%

77%

71%


The indicated muscles were dissected from control or tumor-bearing (C26) mice three weeks following tumor transplant and their wet mass evaluated. Reported is the mean ± SEM of at least three independent experiments (for each data point, the number of replicates, "n", is: 4 < n < 10). Two-way ANOVA (F = 92.3, p < 0.0001 between rows; F = 534.9, p < 0.0001 between columns) indicates a statistically significant effect on muscle mass, independently of muscle type, induced by the presence of the tumor. * = p < 0.01 versus matching control by Student's t test.

Aulino et al. BMC Cancer 2010 10:363   doi:10.1186/1471-2407-10-363

Open Data