BMC Cancer

official impact factor 3.15

Open Access Research article

A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole

Zaida Garcia-Casado1, Angel Guerrero-Zotano2, Antonio Llombart-Cussac3, Ana Calatrava4, Antonio Fernandez-Serra1, Amparo Ruiz-Simon2, Joaquin Gavila2, Miguel A Climent2, Sergio Almenar4, Jose Cervera-Deval6, Josefina Campos7, Carlos V Albaladejo7, Antonio Llombart-Bosch5, Vicente Guillem2 and Jose A Lopez-Guerrero1*

  • * Corresponding author: Jose A Lopez-Guerrero jalopez@fivo.org

  • † Equal contributors

Author Affiliations

1 Laboratory of Molecular Biology, Fundación Instituto Valenciano de Oncología, Valencia, Spain

2 Department of Medical Oncology, Fundación Instituto Valenciano de Oncología, Valencia, Spain

3 Department of Medical Oncology, Hospital Arnau de Villanova, Lleida, Spain

4 Department of Pathology, Fundación Instituto Valenciano de Oncología, Valencia, Spain

5 Department of Pathology, University of Valencia, Spain

6 Department of Radiology, Fundación Instituto Valenciano de Oncología, Valencia, Spain

7 Department of Surgery, Fundación Instituto Valenciano de Oncología, Valencia, Spain

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BMC Cancer 2010, 10:36 doi:10.1186/1471-2407-10-36

Published: 9 February 2010

Additional files

Additional file 1:

Table S1. Association of clinical, pathological and genotypic parameters with progression free survival (PFS). This table shows the associations of the clinicopathological and genetic parameters with PFS that have not been statistically significant.

Format: DOC Size: 38KB Download file

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Additional file 2:

Table S2. Association of clinical, histopathological and genotypic parameters with progression free survival (PFS) according to surgery status. This table shows the associations of the clinicopathological and genetic parameters with PFS that have not been statistically significant according to surgery status.

Format: DOC Size: 55KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data