Iripallidal inhibits Akt/mTOR signaling in glioma cells. Western blot analysis was performed to determine the status of Akt/mTOR pathway in A172, LN229, T98G and U87MG glioma cells treated with 20 μM of Iripallidal for 24 hrs. A decrease in pAkt, pmTOR, pP70S6 kinase and pS6 kinase levels was observed upon Iripallidal treatment. Representative blot is shown from three independent experiments with identical results. C and I denote control and Iripallidal, respectively. Blots were reprobed for β-actin to establish equivalent loading.
Koul et al. BMC Cancer 2010 10:328 doi:10.1186/1471-2407-10-328