Table 3

Associations between the serum concentrations of tamoxifen, estrogens, FSH1, and SHBG

Variables

Tamoxifen

4OHtam

4OHNDtam

NDtam

NDDtam

TamNox

SHBG


All (n = 90)

r

r

r

r

r

r

r

E2

0.295*

0.131

0.211

0.148

0.315**

0.232

-0.048

E1

0.297*

0.133

0.152

0.226

0.330**

0.292*

-0.002

E1S

0.254

0.119

0.118

0.247

0.194

0.284*

-0.445**

FSH

0.118

0.065

0.269*

0.134

0.031

0.178

0.095

SHBG

-0.027

0.034

0.088

0.000

0.048

0.103

Wt/Wt EM CYP2D6 (n = 51)

FSH

0.151

0.133

0.386*

0.148

0.133

0.259

0.224


1FSH, Follicle Stimulating Hormone; SHBG, sex hormone binding globulin; 4OHtam, 4-hydroxytamoxifen; 4OHNDtam, 4-hydroxy-N-demethyltamoxifen; NDtam, N-demethyltamoxifen; NDDtam, N-dedimethyltamoxifen; tamNox, tamoxifen-N-oxide; r, coefficient; E2, estradiol; E1, estrone; E1S, estrone sulfate; Wt/Wt EM, wild type/wild type extensive metabolizer CYP2D6.

r and p values are derived from two-tailed Spearman correlation rank test. The p-values are given after Bonferroni correction for multiple (n = 5) comparisons within this data set, *p < 0.05, and **p < 0.01.

Gjerde et al. BMC Cancer 2010 10:313   doi:10.1186/1471-2407-10-313

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