Open Access Highly Accessed Research article

Analysis of gene expression in prostate cancer epithelial and interstitial stromal cells using laser capture microdissection

Jennifer L Gregg1, Kathleen E Brown2, Eric M Mintz12, Helen Piontkivska12 and Gail C Fraizer12*

Author Affiliations

1 School of Biomedical Sciences, Kent State University, Kent, OH, USA

2 Department of Biological Sciences, Kent State University, Kent OH, USA

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BMC Cancer 2010, 10:165  doi:10.1186/1471-2407-10-165

Published: 28 April 2010

Additional files

Additional file 1:

List of genes significantly overexpressed in epithelial tissues as compared to stromal tissues. This table lists 194 genes whose expression is significantly greater in epithelial cells than in stromal cells. Significance was measured by Bayesian paired t-test (using Cyber-T software) and this table is an extended version of Table 2 which ended at p < 10-5.

Format: XLS Size: 42KB Download file

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Additional file 2:

List of genes significantly overexpressed in stromal tissues as compared to epithelial tissues. This table lists 302 genes whose expression is significantly greater in stromal cells than in epithelial cells. Significance was measured by Bayesian paired t-test (using Cyber-T software) and this table is an extended version of Table 3 which ended at p < 10-5.

Format: XLS Size: 59KB Download file

This file can be viewed with: Microsoft Excel Viewer

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Additional file 3:

Lists of Gene Ontology Biological Process (GO_BP) terms that are overrepresented in stromal (A) and epithelial (B) tissues (per DAVID analysis). This table lists gene functional classification clustering analysis of 194 genes that were elevated in epithelial cells and 302 genes elevated in stromal tissue (from Files 1 and 2, above). Clustering analysis was performed using DAVID and this table is an extension of Table 4 which listed only categories with enrichment scores >1.0.

Format: XLS Size: 43KB Download file

This file can be viewed with: Microsoft Excel Viewer

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