Email updates

Keep up to date with the latest news and content from BMC Cancer and BioMed Central.

Open Access Research article

Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma

Rene' G Feichtinger, Franz Zimmermann, Johannes A Mayr, Daniel Neureiter, Cornelia Hauser-Kronberger, Freimut H Schilling, Neil Jones, Wolfgang Sperl and Barbara Kofler*

BMC Cancer 2010, 10:149  doi:10.1186/1471-2407-10-149

PubMed Commons is an experimental system of commenting on PubMed abstracts, introduced in October 2013. Comments are displayed on the abstract page, but during the initial closed pilot, only registered users can read or post comments. Any researcher who is listed as an author of an article indexed by PubMed is entitled to participate in the pilot. If you would like to participate and need an invitation, please email, giving the PubMed ID of an article on which you are an author. For more information, see the PubMed Commons FAQ.

Inhibition of SDH in brain

Heikki Savolainen   (2010-07-09 17:21)  Dept. of Occup. Safety & Hlth., Tampere, Finland email

Dear Editor,

The highly interesting finding that the succinate dehydrogenase (SDH) activity was very low in malignant cells in brain while the enzyme activity was not affected in kidney cells (1) points at the possibility that a particular, possibly epigenetic, factor was involved.

The case is that alkoxyacetic acids which inhibit the SDH activity in kidney (2,3) do so also in brain (4). The low SDH acivity in tumor cells could be associated with the so-called Warburg effect. One may speculate that tumor cells can inhibit the enzyme or the translation of its gene by a hypothetical endogenous factor.

1 Feichtinger RG, Zimmermann F, Mayr JA, et al. BMC Cancer 2010;10:149

2 Laitinen J, Liesivuori J, Turunen T, Savolainen H. Chemosphere 1994;29:781

3 Liesivuori J, Laitinen J, Savolainen H. Arch Toxicol 1999;73:229

4 Savolainen H. Environ Res 1980;22:423.

Competing interests



Post a comment