Figure 4.

Histopathology analysis of normal lung (A), lung metastasis from untreated mice, control (B), lung metastasis from mice treated with the vehicle (C) and lung metastasis from mice treated with M8 (D). A significant difference was observed in tumor nodule pattern distribution, concentration and area. After M8 treatment (D), tumor nodules (arrows) were smaller and organized in a predominantly peripheral distribution, whereas in the control and vehicle groups the nodules were larger and distributed in the lung parenchyma (B and C, respectively).