Table 8

Impact of maternal hyperoxygenation for impaired fetal growth on stillbirth and perinatal mortality


Location and Type of Study


Stillbirths/Perinatal Outcomes

Reviews and meta-analyses

Say et al. 2003 [119]

Italy, UK, South Africa.

Meta-analysis (Cochrane). 3 RCTs included (N = 94 women).

To assess the effects of maternal oxygen therapy (intervention) vs. management without additional oxygen (controls) in suspected impaired fetal growth on fetal growth and perinatal outcome.

PMR: RR = 0.50 (95% CI: 0.32 – 0.81).

[15/46 vs. 31/48 in intervention and control groups, respectively].

Intervention studies

Battaglia et al. 1994 [120]

Italy (Modena). Tertiary referral hospital (University of Modena).

Quasi-RCT. N = 38 patients with intrauterine growth retardation (N = 18 intervention group, N = 20 controls).

Compared the impact on fetal survival of bed rest plus humidified 55% oxygen at a rate of 8 l/min continuously (intervention) vs. bed rest (plus anti-hypertensive treatment, when necessary).

Ultrasound assessment of amniotic fluid volume was performed on alternate days, and the fetal abdominal circumference was evaluated weekly. Doppler analysis of fetal/maternal circulation was performed upon the patient's arrival at hospital, after 12 h, and thereafter on alternate days until parturition.

PMR: No deaths.

Darmstadt et al. BMC Pregnancy and Childbirth 2009 9(Suppl 1):S6   doi:10.1186/1471-2393-9-S1-S6

Open Data