Table 13

Impact of antibiotics for PPROM/PROM on stillbirth and perinatal outcomes


Location and Type of Study


Stillbirths/Perinatal Outcomes

Reviews and meta-analyses

Flenady and King 2002 [151]



Meta-analysis (Cochrane). 2 RCTs included (N = 838 women).

Compared the impact of any antibiotic (intervention) vs. no antibiotic (controls) in cases of PROM ≥ 36 wks' gestation.

PMR: RR = 0.98 (95% CI: 0.14 – 6.89) [NS]

[2/426 vs. 2/412 in intervention vs. control groups, respectively].

Kenyon et al. 2003 [150]

Mozambique, Norway, Sweden, USA, Spain, UK, Finland, Chile, Denmark.

Meta-analysis (Cochrane). 19 RCTs included (N = 6411).

Compared the impact of any antibiotic (intervention) vs. placebo (controls) in cases of PPROM.

PMR/death before hospital discharge: RR = 0.90 (95% CI: 0.74–1.10) [NS] [data from 13 RCTs].

[281/4374 vs. 148/2037 in intervention vs. control groups, respectively].

Intervention studies

Kenyon et al. 2002 [201]

UK and other international sites. Multicentre.

RCT. Pregnant women (N = 4826) with PPROM.

Assessed the effects of co-amoxiclav and erythromycin singly and in combination: 325 mg co-amoxiclav plus 250 mg erythromycin (group 1), co-amoxiclav plus erythromycin placebo (group 2), erythromycin plus co-amoxiclav placebo (group 3), or co-amoxiclav placebo plus erythromycin placebo (group 4). Antibiotics given 4× daily for 10 d or until delivery.

NMR: 5.2% vs. 5.7% vs. 6.2% in erythromycin (group 3), co-amoxiclav (group 2) and placebo (group 4), respectively.

Major neonatal cerebral abnormality lower with erythromycin vs. placebo or co-amoxiclav.

Menezes et al. BMC Pregnancy and Childbirth 2009 9(Suppl 1):S4   doi:10.1186/1471-2393-9-S1-S4

Open Data