Table 1

Published studies evaluating doses of oxytocin (syntocinon)

Author, citation

Study design

Exposures

Outcome measures

Results

Conclusions


Sarna MC et al

Anesth Analg 1997

84:753–6.

RCT

40 women

Elective CS/regional

Oxytocin after cord clamping

5 IU vs 10 IU vs 15 IU vs 20 IU

Linear analogue of uterine tone

EBL

ΔHCT (pre-op/post-op)

No difference in any outcomes

No benefit in doses exceeding 5 IU

Zarzur

Anesth Analg 1998

86:1334.

Dose-finding

20 women

Elective CS

Oxytocin dosing

Uterine contractility

Side effects

3 IU oxytocin

Satisfactory

No side effects

Low dose 3 IU sufficient

Carvalho JC et al

Obstet Gynecol 2004

104:1005–10.

Dose-finding

RCT single blind

40 women

Elective CS/regional

Titrating increments of 0.5 IU oxytocin bolus

Infusion 2.4 IU/hr

Minimum effective dose ED

Uterine contraction

EBL (calculated)

ED90 at 0.35 IU

100% at 1.0 IU

Low dose bolus < 5 IU effective

Balki M et al

Obstet Gynecol 2006

107:45–50.

Dose-finding

RCT single blind

30 women

CS for labor arrest

Titrating increments of 0.5 IU oxytocin bolus

Infusion 2.4 IU/hr

Minimum effective dose ED

Uterine contraction

EBL (calculated)

ED90 at 3.0 IU

Much higher dose than for elective CS

Suggest alternative agent for non-elective


Murphy et al. BMC Pregnancy and Childbirth 2009 9:36   doi:10.1186/1471-2393-9-36

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