Table 1 |
|||||
|
Published studies evaluating doses of oxytocin (syntocinon) |
|||||
|
Author, citation |
Study design |
Exposures |
Outcome measures |
Results |
Conclusions |
|
|
|||||
|
Sarna MC et al Anesth Analg 1997 84:753–6. |
RCT 40 women Elective CS/regional |
Oxytocin after cord clamping 5 IU vs 10 IU vs 15 IU vs 20 IU |
Linear analogue of uterine tone EBL ΔHCT (pre-op/post-op) |
No difference in any outcomes |
No benefit in doses exceeding 5 IU |
|
Zarzur Anesth Analg 1998 86:1334. |
Dose-finding 20 women Elective CS |
Oxytocin dosing |
Uterine contractility Side effects |
3 IU oxytocin Satisfactory No side effects |
Low dose 3 IU sufficient |
|
Carvalho JC et al Obstet Gynecol 2004 104:1005–10. |
Dose-finding RCT single blind 40 women Elective CS/regional |
Titrating increments of 0.5 IU oxytocin bolus Infusion 2.4 IU/hr |
Minimum effective dose ED Uterine contraction EBL (calculated) |
ED90 at 0.35 IU 100% at 1.0 IU |
Low dose bolus < 5 IU effective |
|
Balki M et al Obstet Gynecol 2006 107:45–50. |
Dose-finding RCT single blind 30 women CS for labor arrest |
Titrating increments of 0.5 IU oxytocin bolus Infusion 2.4 IU/hr |
Minimum effective dose ED Uterine contraction EBL (calculated) |
ED90 at 3.0 IU |
Much higher dose than for elective CS Suggest alternative agent for non-elective |
|
|
|||||
|
Murphy et al. BMC Pregnancy and Childbirth 2009 9:36 doi:10.1186/1471-2393-9-36 |
|||||
