Table 3

Reported adverse events in all included trials

Adverse event

Frequency (%)

Atosiban

Frequency (%)

Betamimetics

Relative risk and Confidence Intervals

p-value

Tachycardia

3.90%

56.30%

RR = 0.07,

95% CI = 0.05, 0.1

<0.001

Palpitation

2.40%

20.40%

RR = 0.12,

95% CI = 0.06, 0.22

<0.001

Vomiting

5.90%

19.20%

RR = 0.27,

95% CI = 0.18, 0.4

<0.001

Headache

8.40%

14.10%

RR = 0.59,

95% CI = 0.43, 0.8

<0.001

Hyperglycaemia

7.80%

13.30%

RR = 0.57,

95% CI = 0.4, 0.89

0.001

Tremor

0.80%

12.20%

RR = 0.08,

95% CI = 0.04, 0.19

<0.001

Nausea

8.70%

10.50%

RR = 0.79,

95% CI = 0.57, 1.08

0.135

Dyspnoea

0.60%

8.50%

RR = 0.09,

95% CI = 0.04, 0.23

<0.001

Chest pain

1.70%

8.00%

RR = 0.18,

95% CI = 0.09, 0.38

<0.001

Hypokalemia

0.70%

7.10%

RR = 0.13,

95% CI = 0.05, 0.36

<0.001

Hypotension

2.80%

5.00%

RR = 0.6,

95% CI = 0.29, 1.11

0.1

Anxiety

1.50%

3.80%

RR = 0.43,

95% CI = 0.2, 0.91

0.027

Syncope

0.60%

0.50%

RR = 1.02,

95% CI = 0.17, 5.98

0.984

Pulmonary oedema

0.30%

0.50%

RR = 0.6,

95% CI = 0.08, 4.45

0.614

Myocardial ischemia

0.00%

0.30%

RR = 0.34,

95% CI = 0.01, 8.3

0.509

Foetal tachycardia

2.90%

21.10%

RR = 0.14,

95% CI = 0.08, 0.23

<0.001

Wex et al. BMC Pregnancy and Childbirth 2009 9:23   doi:10.1186/1471-2393-9-23