Email updates

Keep up to date with the latest news and content from BMC Pregnancy and Childbirth and BioMed Central.

Open Access Research article

Sublingual misoprostol versus standard surgical care for treatment of incomplete abortion in five sub-Saharan African countries

Tara Shochet1, Ayisha Diop1*, Alioune Gaye2, Madi Nayama3, Aissata Bal Sall4, Fawole Bukola5, Thieba Blandine6, Okunlola Michael Abiola5, Blami Dao7, Ogunbode Olayinka5 and Beverly Winikoff1

Author Affiliations

1 Gynuity Health Projects, 15 E. 26th St. Suite 801, New York, NY 10010, USA

2 Centre de Sante le Roi Baudouin, Roi Baudouin Guédiawaye, Senegal

3 Issaka Gazoby Maternity Hospital, Niamey, Niger

4 Cheikh Zayed Hospital, Nouakchott, Mauritania

5 Department of Obstetrics & Gynecology, University College Hospital Ibadan, Oyo State, Nigeria

6 Centre Hospitalier National Yalgado Ouédraogo, Ouagadougou, Burkina Faso

7 Centre Hospitalier National Souro Sanou, Bobo Dioulasso, Burkina Faso

For all author emails, please log on.

BMC Pregnancy and Childbirth 2012, 12:127  doi:10.1186/1471-2393-12-127

Published: 14 November 2012

Abstract

Background

In low-resource settings, where abortion is highly restricted and self-induced abortions are common, access to post-abortion care (PAC) services, especially treatment of incomplete terminations, is a priority. Standard post-abortion care has involved surgical intervention but can be hard to access in these areas. Misoprostol provides an alternative to surgical intervention that could increase access to abortion care. We sought to gather additional evidence regarding the efficacy of 400 mcg of sublingual misoprostol vs. standard surgical care for treatment of incomplete abortion in the environments where need for economical non-surgical treatments may be most useful.

Methods

A total of 860 women received either sublingual misoprostol or standard surgical care for treatment of incomplete abortion in a multi-site randomized trial. Women with confirmed incomplete abortion, defined as past or present history of vaginal bleeding during pregnancy and an open cervical os, were eligible to participate. Participants returned for follow-up one week later to confirm clinical status. If abortion was incomplete at that time, women were offered an additional follow-up visit or immediate surgical evacuation.

Results

Both misoprostol and surgical evacuation are highly effective treatments for incomplete abortion (misoprostol: 94.4%, surgical: 100.0%). Misoprostol treatment resulted in a somewhat lower chance of success than standard surgical practice (RR = 0.90; 95% CI: 0.89-0.92). Both tolerability of side effects and women’s satisfaction were similar in the two study arms.

Conclusion

Misoprostol, much easier to provide than surgery in low-resource environments, can be used safely, successfully, and satisfactorily for treatment of incomplete abortion. Focus should shift to program implementation, including task-shifting the provision of post-abortion care to mid- and low- level providers, training and assurance of drug availability.

Trial registration

This study has been registered at clinicaltrials.gov as NCT00466999 and NCT01539408

Keywords:
Misoprostol; Manual vacuum aspiration (MVA); Incomplete abortion; Post-abortion care (PAC)