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Open Access Highly Accessed Research article

No association between polymorphisms/haplotypes of the vascular endothelial growth factor gene and preeclampsia

Idalia Garza-Veloz14, Claudia Castruita-De la Rosa1, Raul Cortes-Flores2, Victoria Martinez-Gaytan2, Jose E Rivera-Muñoz1, Elda A Garcia-Mayorga1, Esteban Meza-Lamas3, Augusto Rojas-Martinez45, Rocio Ortiz-Lopez45 and Margarita L Martinez-Fierro1*

Author Affiliations

1 Laboratorio de Medicina Molecular, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas, Mexico

2 Unidad Medica Materno-Fetal del Noreste, Unidad Medica de Alta Especialidad No. 23 Instituto Mexicano del Seguro Social, Avenida Constitucion y Felix U. Gomez, Col. Centro, Monterrey, Mexico

3 Unidad Academica de Enfermeria, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, Zacatecas, Mexico

4 Department of Biochemistry and Molecular Medicine, University Hospital Universidad Autonoma de Nuevo Leon, Av. F. I. Madero S/N, Col. Mitras Centro, Monterrey, Mexico

5 Centro de Investigacion y Desarrollo en Ciencias de la Salud, Universidad Autonoma de Nuevo Leon, Calle Carlos Canseco S/N, Col. Mitras Centro, Monterrey, Mexico

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BMC Pregnancy and Childbirth 2011, 11:35  doi:10.1186/1471-2393-11-35

Published: 16 May 2011

Abstract

Background

Preeclampsia (PE) is the first worldwide cause of death in pregnant women, intra-uterine growth retardation, and fetal prematurity. Some vascular endothelial grown factor gene (VEGF) polymorphisms have been associated to PE and other pregnancy disturbances. We evaluated the associations between VEGF genotypes/haplotypes and PE in Mexican women.

Methods

164 pregnant women were enrolled in a case-control study (78 cases and 86 normotensive pregnant controls). The rs699947 (-2578C/A), rs1570360 (-1154G/A), rs2010963 (+405G/C), and rs25648 (-7C/T), VEGF variants were discriminated using Polymerase Chain Reaction - Restriction Fragment Length Polymorphism (PCR-RFLP) methods or Taqman single nucleotide polymorphism (SNP) assays.

Results

The proportions of the minor allele for rs699947, rs1570360, rs2010963, and rs25648 VEGF SNPs were 0.33, 0.2, 0.39, and 0.17 in controls, and 0.39, 0.23, 0.41, and 0.15 in cases, respectively (P values > 0.05). The most frequent haplotypes of rs699947, rs1570360, rs2010963, and rs25648 VEGF SNPs, were C-G-C-C and C-G-G-C with frequencies of 0.39, 0.21 in cases and 0.37, 0.25 in controls, respectively (P values > 0.05)

Conclusion

There was no evidence of an association between VEGF alleles, genotypes, or haplotypes frequencies and PE in our study.