Maternal thyroid function and the outcome of external cephalic version: a prospective cohort study
1 Department of Primary Care, University of Tilburg, Tilburg, the Netherlands
2 Department of Obstetrics and Gynecology, Catharina Hospital, Eindhoven, the Netherlands
3 Department of Pediatrics, Alberta Children's Hospital, University of Calgary, Canada
4 Department of Clinical Chemistry, Máxima Medical Centre, Veldhoven, the Netherlands
5 Department of Biomedical Engineering, University of Technology, Eindhoven, the Netherlands
6 Department of Obstetrics and Gynecology, Máxima Medical Centre, Veldhoven, the Netherlands
7 Department of Electrical Engineering, University of Technology, Eindhoven, the Netherlands
BMC Pregnancy and Childbirth 2011, 11:10 doi:10.1186/1471-2393-11-10Published: 26 January 2011
To investigate the relation between maternal thyroid function and the outcome of external cephalic version (ECV) in breech presentation.
Prospective cohort study in 141 women (≥ 35 weeks gestation) with a singleton fetus in breech. Blood samples for assessing thyroid function were taken prior to ECV. Main outcome measure was the relation between maternal thyroid function and ECV outcome indicated by post ECV ultrasound.
ECV success rate was 77/141 (55%), 41/48 (85%) in multipara and 36/93 (39%) in primipara. Women with a failed ECV attempt had significantly higher TSH concentrations than women with a successful ECV (p < 0.001). Multiple logistic regression showed that TSH (OR: 0.52, 95% CI: 0.30-0.90), nulliparity (OR: 0.11, 95% CI: 0.03-0.36), frank breech (OR: 0.30, 95% CI: 0.10-0.93) and placenta anterior (OR: 0.31, 95% CI: 0.11-0.85) were independently related to ECV success.
Higher TSH levels increase the risk of ECV failure.
Trial registration number