Table 1 |
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Normal Gestational Biology |
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Overarching Goal: To gain comprehensive knowledge of the biology and regulation of human gestational biology in order to identify pathways and critical junctures to facilitate prediction and prevention of preterm birth and stillbirth |
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Milestones* |
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Output |
Post-Conference (by 2010) |
Short-Term (by 2012) |
Intermediate (by 2015) |
Long-Term (beyond 2015) |
Success Metrics |
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A. Define phenotype of normal pregnancy |
1. Systematic review of existing knowledge 2. Develop "best guess" phenotype of normal gestation |
3. Prospective tissue repository of normal gestation 4. Utilize "systems biology" technology 5. Identify critical biomarkers, including those governing parturitional stages and biomarkers of placentation, fetal growth and development |
6. Develop "lateral flow" multi-analyte diagnostic platforms 7. Begin application of diagnostic tools in LMICs |
8. Validate multi-analyte platforms for both HICs and LMICs |
• Comprehensive atlas of normal human gestation • Web-based tool for providers and patients |
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B. Develop animal and in-silico models of normal parturition |
1. Systematic review of existing knowledge |
2. Explore and develop animal models including genetically altered mice, non-human primates, others 3. Computer modeling 4. Integrate modeling with animal models |
5. Validate models 6. Predict outcome based on modeling |
7. Use models to predict therapeutic targets and treatments |
• Improved animal models to identify key regulatory steps • Enhanced use of in-silico models |
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C. Define regulators and mechanisms governing stages of parturition |
1. Systematic review of existing knowledge |
2. Identify critical biomarkers governing parturitional stages and transitions |
3. Identify potential therapeutic targets for treatment of PTL 4. Develop therapeutic interventions based upon selected targets 5. Collaborate with Intervention Development to prioritize potential therapeutic interventions |
6. Develop therapeutic interventions based upon selected targets and scaling feasibility |
• Identify novel therapeutic and diagnostic targets • Web-based tool for providers and patients |
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*Milestones are to be reached by no later than December of the year indicated. |
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Rubens et al. BMC Pregnancy and Childbirth 2010 10(Suppl 1):S7 doi:10.1186/1471-2393-10-S1-S7 |
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