Screenshot image from Brainsight stereotactic image guidance software used to localize motor hotspot. A 3-dimensional reconstruction (A, bottom image) of a single T1 magnetic resonance scan of the brain (B) with positioning of the transcranial magnetic stimulation coil. An infrared optical sensor co-registers the position and orientation of the TMS coil relative to small refractory markers on the subject's cranium (A, top image). This provides the investigator with real-time information regarding the brain locus that will receive TMS given a position and orientation of the TMS coil, in order to minimize spatial variability in TMS application. (Image courtesy of Roch M. Comeau, Brainsight, Rogue Industries, Canada.).
Fisher et al. BMC Neurology 2009 9:20 doi:10.1186/1471-2377-9-20