|
Odds Ratio for AD in all genotypes in patients with/without first degree relatives with dementia |
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| Genotypes |
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|
|
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| ε2/ε2 |
ε2/ε3 |
ε2/ε4 |
ε3/ε3 |
ε3/ε4 |
ε4/ε4 |
|
|
|
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| Odds Ratio (376 AD patients; 561 control individuals) |
0.7 |
0.9 |
3.2 |
1 |
4.2 |
12.9 |
| CI |
0.01–7.57 |
0.51–1.41 |
1.67–6.18 |
Ref |
2.98–5.89 |
6.64–26.68 |
| p value |
1.00 |
0.62 |
< 0.001 |
< 0.001 |
< 0.001 |
|
|
|
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| Odds Ratio, AD patients with no family history of dementia (n = 149) |
1.1* |
0.7 |
2.8 |
1 |
2.9 |
8.1 |
| CI |
0.00–0.16 |
0.34–1.47 |
1.17–6.44 |
Ref |
1.83–4.58 |
3.53–19.18 |
| p value |
1.00 |
0.47 |
0.021 |
< 0.001 |
< 0.000 |
|
|
|
||||||
| Odds Ratio, AD patients with first degree relative with dementia (n = 213) |
1.7 |
1.0 |
4.0 |
1 |
5.9 |
18.7 |
| CI |
0.03–17.27 |
0.47–1.89 |
1.79–8.86 |
Ref |
3.88–9.15 |
8.97–41.40 |
| p value |
1.0 |
1.0 |
< 0.001 |
< 0.001 |
< 0.001 |
|
|
SD = Standard Deviation CI = 95% confidence interval Ref = Reference category *The Median unbiased estimate is given, since the Maximum Likelihood estimate does not exist. | ||||||
Sando et al. BMC Neurology 2008 8:9 doi:10.1186/1471-2377-8-9 |
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